ADAR1 isoform involvement in embryonic lethality
نویسندگان
چکیده
منابع مشابه
ADAR1 isoform involvement in embryonic lethality.
Letters to the editor recently published in PNAS (1, 2) challenged and defended a claim made on a recent article (3). Matthaei et al. (1) questioned whether the animal model used by Ward et al. (3) was adequate to support their claim that the P150 isoform of the RNA editing enzyme adenosine deaminase 1 (ADAR1) is required for embryogenesis. We believe the question remains open and present data ...
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The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interferon induction and die by embryonic day E12.5. We demonstrate that Adar1 embryonic lethality is res...
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We read with interest the manuscript by Ward et al. (1) in PNAS in which selective disruption of the p150 isoform, but not the p110 isoform, of the RNA editing enzyme Adenosine Deaminase 1 (ADAR1) was reported to cause early embryonic lethality. ADAR1 exists in two molecular weight isoforms: a long protein of 150 kDa (p150), which is expressed from an interferoninducible promoter using a transl...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1105004108